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The significance of prolonged and saddleback fever in hospitalised adult dengue
Dengue fever is gaining importance in Singapore with an increase in the number of cases and mortality in recent years. Although prolonged and saddleback fever have been reported in dengue fever, there are no specific studies ...
NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication
The protein–RNA interactions within the flavivirus replication complex (RC) are not fully understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase bound to the conserved 5′ genomic RNA ...
Intra-epidemic evolutionary dynamics of a dengue virus type 1 population reveal mutant spectra that correlate with disease transmission
Dengue virus (DENV) is currently the most prevalent mosquito-borne viral pathogen. DENVs naturally exist as highly heterogeneous populations. Even though the descriptions on DENV diversity are plentiful, only a few studies ...
Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation
We previously showed that luteolin, a well-known plant-derived component found in the “heat clearing” class of Traditional Chinese Medicine (TCM) herbs, is an uncompetitive inhibitor (Ki 58.6 μM) of the host proprotein ...
Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype–anti-idiotype Fab complex
A detailed understanding of the fine specificity of serotype-specific human antibodies is vital for the development and evaluation of new vaccines for pathogenic flaviviruses such as dengue virus (DENV) and Zika virus. In ...