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NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication

Swarbrick, Crystall M. D.; Basavannacharya, Chandrakala; Chan, Kitti W. K.; Chan, Shu-Ann; Singh, Daljit; Wei, Na; Phoo, Wint Wint; Luo, Dahai; Lescar, Julien; Vasudevan, Subhash G. (2017)

The protein–RNA interactions within the flavivirus replication complex (RC) are not fully understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase bound to the conserved 5′ genomic RNA ...