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NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35
The emergence of drug-resistant malaria parasites is the major threat to effective malaria control, prompting a search for novel compounds with mechanisms of action that are different from the traditionally used drugs. The ...
Macro histone H2A1.2 (MacroH2A1) protein suppresses mitotic kinase VRK1 during interphase
VRK1-mediated phosphorylation of histone H3 should be restricted in mitosis for consistent cell cycling, and defects in this process trigger cellular catastrophe. However, an interphasic regulator against VRK1 has not been ...