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The natively disordered loop of Bcl-2 undergoes phosphorylation-dependent conformational change and interacts with Pin1
Bcl-2 plays a central role in the regulation of apoptosis. Structural studies of Bcl-2 revealed the presence of a flexible and natively disordered loop that bridges the Bcl-2 homology motifs, BH3 and BH4. This loop is ...
Macro histone H2A1.2 (MacroH2A1) protein suppresses mitotic kinase VRK1 during interphase
VRK1-mediated phosphorylation of histone H3 should be restricted in mitosis for consistent cell cycling, and defects in this process trigger cellular catastrophe. However, an interphasic regulator against VRK1 has not been ...