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Preparation of mica supported lipid bilayers for high resolution optical microscopy imaging
Supported lipid bilayers (SLBs) are widely used as a model for studying membrane properties (phase separation, clustering, dynamics) and its interaction with other compounds, such as drugs or peptides. However SLB ...
Terahertz transparency of optically opaque metallic films
Here we present an alternative approach to design a freestanding transparent conducting device for wide-angle and polarization-insensitive incidence of electromagnetic waves at terahertz frequencies. It is realized by ...
Using neuroplasticity principles to delay or reverse effects of chronic disease, disability and ageing: A new look at disease biology
Unconscious adaptations in posture and muscle use take place in the course of ageing, progression of chronic conditions or a sudden incident like stroke resulting in physical disability. In many cases, the person is unable ...
Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis
In contrast to the intensely studied genetic and epigenetic changes that induce host cell transformation to initiate tumor development, those that promote the malignant progression of cancer remain poorly defined. As ...
Dicyanopyrazine-derived push-pull chromophores for highly efficient photoredox catalysis
Here, we report dicyanopyrazine (DPZ)-derived push–pull chromophores, easily prepared and tunable organic compounds, as new kinds of photoredox catalysts. In particular, the DPZ derivative H, containing 2-methoxythienyl ...
Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs
An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the ...
The endoplasmic reticulum stress sensor IRE1α protects cells from apoptosis induced by the coronavirus infectious bronchitis virus
The unfolded-protein response (UPR) is a signal transduction cascade triggered by perturbation of the homeostasis of the endoplasmic reticulum (ER). UPR resolves ER stress by activating a cascade of cellular responses, ...
Impact of quantum-classical correspondence on entanglement enhancement by single-mode squeezing
Quantum entanglement between two field modes can be achieved through the collective squeezing of the two respective modes. If single-mode squeezing is performed prior to such a two-mode squeezing, an enhancement of ...
Structure of a conserved Golgi complex-targeting signal in coronavirus envelope proteins
Coronavirus envelope (CoV E) proteins are ∼100-residue polypeptides with at least one channel-forming α-helical transmembrane (TM) domain. The extramembrane C-terminal tail contains a completely conserved proline, at the ...
Nonlinear optics : asymmetry from symmetry
An unusual form of symmetry breaking in coupled microresonators with balanced optical gain and loss is now exploited to realize a novel type of optical isolator.