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NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication
The protein–RNA interactions within the flavivirus replication complex (RC) are not fully understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase bound to the conserved 5′ genomic RNA ...
Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation
We previously showed that luteolin, a well-known plant-derived component found in the “heat clearing” class of Traditional Chinese Medicine (TCM) herbs, is an uncompetitive inhibitor (Ki 58.6 μM) of the host proprotein ...