Now showing items 31-40 of 67
Molecular characterization of the recombinant A-chain of a Type II ribosome-inactivating protein (RIP) from viscum album coloratum and structural basis on its ribosome-inactivating activity and the sugar-binding properties of the B-chain
Mistletoe (Viscum album) lectins, which are classified as a type II ribosome-inactivating protein (RIP) due to their unique biological function and the potential medical and therapeutic application in cancer cells, receive ...
FKBP38 protects Bcl-2 from caspase-dependent degradation
The cellular processes that regulate Bcl-2 at the posttranslational levels are as important as those that regulate bcl-2 synthesis. Previously we demonstrated that the suppression of FK506-binding protein 38 (FKBP38) ...
Expression, purification and characterization of C2 domain of milk fat globule-EGF-factor 8-L
Milk fat globule-EGF-factor 8-L (MFG-E8L) is secreted by activated macrophages and functions as a linker protein or opsonin between the dying cells and phagocytes. MFG-E8L recognizes the apoptotic or dying cells by ...
The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)
Bcl-2 contains an unusually long loop between the first and the second helices. This loop has been shown to be highly flexible based on NMR and X-ray crystallographic analyses of this region. Bcl-2 is regulated at the ...
Molecular and structural characterization of the domain 2 of Hepatitis C virus non-structural protein 5A
Hepatitis C virus (HCV) non-structural protein 5A protein (NS5A), which consists of three functional domains, is involved in regulating viral replication, interferon resistance, and apoptosis. Recently, the three-dimensional ...
NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35
The emergence of drug-resistant malaria parasites is the major threat to effective malaria control, prompting a search for novel compounds with mechanisms of action that are different from the traditionally used drugs. The ...
Solution structure of FK506 binding domain (FKBD) of Plasmodium falciparum FK506 binding protein 35 (PfFKBP35)
No abstract available.
Co-delivery of drugs and DNA from cationic core–shell nanoparticles self-assembled from a biodegradable copolymer
Non-viral gene-delivery systems are safer to use and easier to produce than viral vectors, but their comparatively low transfection efficiency has limited their applications. Co-delivery of drugs and DNA has been proposed ...
Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins
The identification of off-target binding of drugs is a key to repositioning drugs to new therapeutic categories. Here we show the universal interactions of the p53 transactivation domain (p53TAD) with ...
Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD)
FK-506 binding protein 38 (FKBP38) interacts with Bcl-2/Bcl-Xl and helps them localize at the mitochondrial membrane (Shirane and Nakayama, 2003). The down-regulation of FKBP38 was shown to influence ...